{"id":1474,"date":"2022-06-15T10:00:02","date_gmt":"2022-06-15T03:00:02","guid":{"rendered":"https:\/\/news.eloqasia.com\/?p=1474"},"modified":"2022-06-17T10:34:00","modified_gmt":"2022-06-17T03:34:00","slug":"hon-hop-khang-the-don-dong-tac-dung-keo-dai-evusheld-giup-ngan-ngua-dang-ke-nguy-co-covid-19-tien-trien-nghiem-trong-hoac-gay-tu-vong-trong-thu-nghiem-tackle-pha-iii","status":"publish","type":"post","link":"https:\/\/news.eloqasia.com\/?p=1474","title":{"rendered":"H\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i Evusheld gi\u00fap ng\u0103n ng\u1eeba \u0111\u00e1ng k\u1ec3 nguy c\u01a1 COVID-19 ti\u1ebfn tri\u1ec3n nghi\u00eam tr\u1ecdng ho\u1eb7c g\u00e2y t\u1eed vong trong th\u1eed nghi\u1ec7m TACKLE pha III"},"content":{"rendered":"

K\u1ebft qu\u1ea3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed The Lancet Respiratory Medicine, ch\u1ee9ng minh l\u1ee3i \u00edch c\u1ee7a b\u1ed9 \u0111\u00f4i kh\u00e1ng th\u1ec3 n\u00e0y trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb COVID-19 ngo\u1ea1i tr\u00fa \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh<\/em><\/p>\n

K\u1ebft qu\u1ea3 chi ti\u1ebft t\u1eeb th\u1eed nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i tr\u00fa TACKLE pha III cho th\u1ea5y, so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, b\u1ed9 \u0111\u00f4i kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng Evusheld<\/em> c\u1ee7a AstraZeneca (<\/em>k\u1ebft h\u1ee3p gi\u1eefa tixagevimab v\u00e0 cilgavimab, tr\u01b0\u1edbc \u0111\u00e2y l\u00e0 AZD7442) c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t th\u1ed1ng k\u00ea v\u00e0 l\u00e2m s\u00e0ng trong vi\u1ec7c ng\u0103n ch\u1eb7n c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ec7nh COVID-19 ti\u1ebfn tri\u1ec3n nghi\u00eam tr\u1ecdng ho\u1eb7c t\u1eed vong do b\u1ea5t k\u1ef3 nguy\u00ean nh\u00e2n n\u00e0o. \u0110\u1ed3ng th\u1eddi, vi\u1ec7c s\u1eed d\u1ee5ng s\u1edbm h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb gi\u00fap \u0111\u1ea1t \u0111\u01b0\u1ee3c c\u00e1c k\u1ebft qu\u1ea3 t\u00edch c\u1ef1c h\u01a1n.1<\/sup><\/p>\n

D\u1eef li\u1ec7u \u0111\u00e3 \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n tr\u00ean t\u1ea1p ch\u00ed The Lancet Respiratory Medicine<\/em>.<\/p>\n

TACKLE \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi l\u1edbn \u0111ang m\u1eafc COVID-19 \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 ho\u1eb7c trung b\u00ecnh, kh\u00f4ng ph\u1ea3i nh\u1eadp vi\u1ec7n, v\u00e0 c\u00f3 bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng trong b\u1ea3y ng\u00e0y tr\u1edf xu\u1ed1ng. Trong th\u1eed nghi\u1ec7m, 90% ng\u01b0\u1eddi tham gia c\u00f3 nguy c\u01a1 COVID-19 ti\u1ebfn tri\u1ec3n nghi\u00eam tr\u1ecdng do c\u00e1c b\u1ec7nh \u0111\u1ed3ng m\u1eafc ho\u1eb7c tu\u1ed5i t\u00e1c cao.1<\/sup><\/p>\n

\u00d4ng Hugh Montgomery, Gi\u00e1o s\u01b0 Y khoa Ch\u0103m s\u00f3c T\u00edch c\u1ef1c t\u1ea1i \u0110\u1ea1i h\u1ecdc College London, V\u01b0\u01a1ng qu\u1ed1c Anh v\u00e0 l\u00e0 nghi\u00ean c\u1ee9u vi\u00ean ch\u00ednh c\u1ee7a th\u1eed nghi\u1ec7m TACKLE, cho bi\u1ebft: \u201cM\u1eb7c d\u00f9 v\u1eafc xin \u0111\u00e3 c\u00f3 nhi\u1ec1u th\u00e0nh c\u00f4ng \u0111\u00e1ng k\u1ec3 nh\u01b0ng nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng nh\u01b0 ng\u01b0\u1eddi l\u1edbn tu\u1ed5i, nh\u1eefng ng\u01b0\u1eddi c\u00f3 b\u1ec7nh \u0111\u1ed3ng m\u1eafc v\u00e0 nh\u1eefng ng\u01b0\u1eddi b\u1ecb suy gi\u1ea3m mi\u1ec5n d\u1ecbch v\u1eabn c\u00f3 nguy m\u1eafc COVID-19 nghi\u00eam tr\u1ecdng. C\u1ea7n c\u00f3 c\u00e1c gi\u1ea3i ph\u00e1p b\u1ed5 sung \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh v\u00e0 gi\u1ea3m g\u00e1nh n\u1eb7ng cho h\u1ec7 th\u1ed1ng ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe, \u0111\u1eb7c bi\u1ec7t l\u00e0 v\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n li\u00ean t\u1ee5c c\u1ee7a c\u00e1c bi\u1ebfn th\u1ec3 m\u1edbi. K\u1ebft qu\u1ea3 TACKLE cho th\u1ea5y r\u1eb1ng m\u1ed9t li\u1ec1u Evusheld <\/em>ti\u00eam b\u1eafp c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n nh\u1eefng ti\u1ebfn tri\u1ec3n nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19 tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y v\u00e0 s\u1ebd c\u00f3 k\u1ebft qu\u1ea3 t\u1ed1t h\u01a1n n\u1ebfu \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng s\u1edbm trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.\u201d<\/p>\n

\u00d4ng Mene Pangalos, Ph\u00f3 Ch\u1ee7 t\u1ecbch \u0111i\u1ec1u h\u00e0nh, BioPharmaceuticals R&D t\u1ea1i AstraZeneca, cho bi\u1ebft: \u201cNh\u1eefng k\u1ebft qu\u1ea3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean The<\/em> Lancet Respiratory Medicine <\/em>\u0111\u00e3 \u0111\u1ed9ng g\u00f3p th\u00eam d\u1eef li\u1ec7u v\u00e0o nh\u1eefng b\u1eb1ng ch\u1ee9ng \u1ee7ng h\u1ed9 vi\u1ec7c s\u1eed d\u1ee5ng b\u1ed9 \u0111\u00f4i kh\u00e1ng th\u1ec3 n\u00e0y cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u1ea7n th\u00eam m\u1ed9t l\u1edbp b\u1ea3o v\u1ec7 tr\u01b0\u1edbc COVID-19. Ch\u00fang t\u00f4i \u0111ang th\u1ea3o lu\u1eadn v\u1edbi c\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd \u0111\u1ec3 x\u00fac ti\u1ebfn vi\u1ec7c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y trong ch\u1ec9 \u0111\u1ecbnh d\u1ef1 ph\u00f2ng l\u1eabn \u0111i\u1ec1u tr\u1ecb, nh\u1eb1m ch\u1ed1ng l\u1ea1i COVID-19 m\u1ed9t c\u00e1ch to\u00e0n di\u1ec7n.”<\/p>\n

B\u1ed9 \u0111\u00f4i kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i n\u00e0y \u0111\u00e3 c\u00f3 m\u1eb7t t\u1ea1i Vi\u1ec7t Nam t\u1eeb th\u00e1ng 3 v\u1eeba qua, c\u0169ng l\u00e0 m\u1ed9t trong nh\u1eefng n\u01b0\u1edbc ch\u00e2u \u00c1 \u0111\u1ea7u ti\u00ean. Thu\u1ed1c n\u00e0y \u0111\u00e3 nh\u1eadn \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p nh\u1eadp kh\u1ea9u \u0111\u1eb7c bi\u1ec7t c\u1ee7a B\u1ed9 Y t\u1ebf. Nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y Evusheld<\/em> v\u1eabn gi\u1eef v\u1eefng kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 tr\u01b0\u1edbc t\u1ea5t c\u1ea3 c\u00e1c bi\u1ebfn th\u1ec3 COVID-19 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u t\u1edbi nay, bao g\u1ed3m c\u1ea3 Omicron.<\/p>\n

Hi\u1ec7n h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1ea1i B\u1ec7nh vi\u1ec7n \u0110a khoa T\u00e2m Anh H\u00e0 N\u1ed9i v\u00e0 TP. H\u1ed3 Ch\u00ed Minh, v\u00e0 s\u1ebd s\u1edbm c\u00f3 m\u1eb7t \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh vi\u1ec7n kh\u00e1c nh\u1eb1m t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn cho ng\u01b0\u1eddi d\u00e2n. Thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh b\u1edfi b\u00e1c s\u0129 d\u00e0nh cho m\u1ee5c \u0111\u00edch d\u1ef1 ph\u00f2ng tr\u01b0\u1edbc ph\u01a1i nhi\u1ec5m COVID-19 \u1edf nh\u1eefng nh\u00f3m b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 ti\u00eam v\u1eafc xin ho\u1eb7c \u0111\u00e3 ti\u00eam nh\u01b0ng kh\u00f4ng c\u00f3 \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ea7y \u0111\u1ee7.<\/p>\n

Trong th\u1eed nghi\u1ec7m TACKLE, so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, m\u1ed9t li\u1ec1u ti\u00eam b\u1eafp Evusheld<\/em> 600mg gi\u1ea3m \u0111\u00e1ng k\u1ec3 nguy c\u01a1 ti\u1ebfn tri\u1ec3n COVID-19 n\u1eb7ng ho\u1eb7c t\u1eed vong (do b\u1ea5t k\u1ef3 nguy\u00ean nh\u00e2n n\u00e0o) t\u1edbi 50% (kho\u1ea3ng tin c\u1eady 95%, 15 – 71; p = 0,010) cho \u0111\u1ebfn ng\u00e0y th\u1ee9 29 \u0111\u1ed1i v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n m\u1eafc COVID-19 t\u1eeb nh\u1eb9 t\u1edbi trung b\u00ecnh, kh\u00f4ng nh\u1eadp vi\u1ec7n, v\u00e0 bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng trong kho\u1ea3ng th\u1eddi gian b\u1ea3y ng\u00e0y tr\u1edf xu\u1ed1ng. \u0110\u00e2y l\u00e0 ti\u00eau ch\u00ed ch\u00ednh c\u1ee7a cu\u1ed9c th\u1eed nghi\u1ec7m.<\/p>\n

Trong c\u00e1c ph\u00e2n t\u00edch \u0111\u1ecbnh tr\u01b0\u1edbc tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb trong v\u00f2ng ba ng\u00e0y k\u1ec3 t\u1eeb khi c\u00f3 xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng, h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y gi\u00fap l\u00e0m gi\u1ea3m nguy c\u01a1 ti\u1ebfn tri\u1ec3n th\u00e0nh COVID-19 n\u1eb7ng ho\u1eb7c t\u1eed vong (do b\u1ea5t k\u1ef3 nguy\u00ean nh\u00e2n n\u00e0o) t\u1edbi 88% so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c (kho\u1ea3ng tin c\u1eady 95%, 9 – 98), v\u00e0 gi\u1ea3m nguy c\u01a1 \u0111\u1ebfn 67% (kho\u1ea3ng tin c\u1eady 95%, 31 – 84) khi ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c ti\u00eam li\u1ec7u ph\u00e1p n\u00e0y trong v\u00f2ng n\u0103m ng\u00e0y k\u1ec3 t\u1eeb khi bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng.1<\/sup><\/p>\n

B\u1ed9 \u0111\u00f4i kh\u00e1ng th\u1ec3 n\u00e0y c\u0169ng gi\u00fap gi\u1ea3m nguy c\u01a1 suy h\u00f4 h\u1ea5p (ti\u00eau ch\u00ed ph\u1ee5) t\u1edbi 72% (95%, 0,3 – 92; p = 0,036). Trong \u0111\u00f3, ch\u1ec9 ba b\u1ec7nh nh\u00e2n ti\u00eam Evusheld <\/em>(0,7%) c\u1ea7n \u0111\u01b0\u1ee3c can thi\u1ec7p b\u1eb1ng c\u00e1c bi\u1ec7n ph\u00e1p th\u00f4ng kh\u00ed nh\u00e2n t\u1ea1o ho\u1eb7c trao \u0111\u1ed5i oxy qua m\u00e0ng ngo\u00e0i c\u01a1 th\u1ec3 (ECMO) so v\u1edbi 11 b\u1ec7nh nh\u00e2n (33%) d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n

Nh\u00ecn chung, <\/em>h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i n\u00e0y \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t trong c\u00e1c th\u1eed nghi\u1ec7m. C\u00e1c bi\u1ebfn c\u1ed1 ngo\u1ea1i \u00fd di\u1ec5n ra \u1edf nh\u00f3m b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c nhi\u1ec1u h\u01a1n nh\u00f3m \u0111\u01b0\u1ee3c ti\u00eam Evusheld <\/em>(EV), v\u1edbi t\u1ef7 l\u1ec7 l\u1ea7n l\u01b0\u1ee3t l\u00e0 36% v\u00e0 29%. Bi\u1ebfn c\u1ed1 ngo\u1ea1i \u00fd th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 vi\u00eam ph\u1ed5i COVID-19, x\u1ea3y ra \u1edf 49 b\u1ec7nh nh\u00e2n (11%) trong nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c v\u00e0 26 b\u1ec7nh nh\u00e2n (6%) trong nh\u00f3m EV. C\u00e1c bi\u1ebfn c\u1ed1 ngo\u1ea1i \u00fd nghi\u00eam tr\u1ecdng di\u1ec5n ra \u1edf 12% b\u1ec7nh nh\u00e2n trong nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c v\u00e0 7% b\u1ec7nh nh\u00e2n trong nh\u00f3m EV1<\/sup>.<\/em> C\u00f3 6 ca t\u1eed vong do COVID-19 trong nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c v\u00e0 3 ca trong nh\u00f3m EV 1<\/sup>.<\/p>\n

TACKLE<\/strong><\/p>\n

TACKLE l\u00e0 th\u1eed nghi\u1ec7m pha III, ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, \u0111a trung t\u00e2m, v\u1edbi m\u1ee5c \u0111\u00edch \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a m\u1ed9t li\u1ec1u Evusheld<\/em> 600mg ti\u00eam b\u1eafp duy nh\u1ea5t so v\u1edbi ti\u00eam gi\u1ea3 d\u01b0\u1ee3c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19 cho b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh. Th\u1eed nghi\u1ec7m \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf 95 \u0111\u1ecba \u0111i\u1ec3m \u1edf Hoa K\u1ef3, M\u1ef9 La-tinh, Ch\u00e2u \u00c2u v\u00e0 Nh\u1eadt B\u1ea3n. 903 ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c ph\u00e2n nh\u00f3m ng\u1eabu nhi\u00ean (1:1). Trong \u0111\u00f3, nh\u00f3m 452 ng\u01b0\u1eddi (n = 452) nh\u1eadn m\u1ed9t li\u1ec1u ti\u00eam AZD7442 v\u00e0 nh\u00f3m 451 ng\u01b0\u1eddi (n = 451) nh\u1eadn 1 li\u1ec1u ti\u00eam gi\u1ea3 d\u01b0\u1ee3c n\u01b0\u1edbc mu\u1ed1i, \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n qua \u0111\u01b0\u1eddng ti\u00eam b\u1eafp, g\u1ed3m hai m\u0169i ti\u00eam ri\u00eang bi\u1ec7t v\u00e0 tu\u1ea7n t\u1ef1.<\/p>\n

Nh\u1eefng ng\u01b0\u1eddi tham gia l\u00e0 ng\u01b0\u1eddi l\u1edbn t\u1eeb 18 tu\u1ed5i tr\u1edf l\u00ean, nhi\u1ec5m COVID-19 \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, kh\u00f4ng ph\u1ea3i nh\u1eadp vi\u1ec7n, v\u00e0 c\u00f3 tri\u1ec7u ch\u1ee9ng trong b\u1ea3y ng\u00e0y ho\u1eb7c \u00edt h\u01a1n. Nh\u1eefng ng\u01b0\u1eddi tham gia c\u00f3 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m kh\u1eb3ng \u0111\u1ecbnh \u0111\u00e3 nhi\u1ec5m SARS-CoV-2, th\u00f4ng qua x\u00e9t nghi\u1ec7m ph\u00e2n t\u1eed (kh\u00e1ng nguy\u00ean ho\u1eb7c axit nucleic) t\u1eeb b\u1ea5t k\u1ef3 m\u1eabu \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p n\u00e0o (v\u00ed d\u1ee5 nh\u01b0 d\u1ecbch h\u1ea7u h\u1ecdng, m\u0169i h\u1ecdng, ph\u1ebft m\u0169i ho\u1eb7c n\u01b0\u1edbc b\u1ecdt). M\u1eabu \u0111\u01b0\u1ee3c thu th\u1eadp kh\u00f4ng qu\u00e1 ba ng\u00e0y tr\u01b0\u1edbc ng\u00e0y \u0111\u1ea7u ti\u00ean c\u1ee7a th\u1eed nghi\u1ec7m. Ng\u01b0\u1eddi tham gia ch\u01b0a \u0111\u01b0\u1ee3c ti\u00eam ph\u00f2ng COVID-19 t\u1ea1i th\u1eddi \u0111i\u1ec3m ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m.<\/p>\n

Ti\u00eau ch\u00ed ch\u00ednh \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c l\u00e0 t\u1ed5 h\u1ee3p c\u1ee7a tr\u01b0\u1eddng h\u1ee3p m\u1eafc COVID-19 nghi\u00eam tr\u1ecdng ho\u1eb7c t\u1eed vong do b\u1ea5t k\u1ef3 nguy\u00ean nh\u00e2n n\u00e0o cho \u0111\u1ebfn ng\u00e0y th\u1ee9 29. C\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng ng\u01b0\u1eddi tham gia s\u1ebd ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c theo d\u00f5i trong 15 th\u00e1ng.<\/p>\n

Kho\u1ea3ng 13% ng\u01b0\u1eddi tham gia t\u1eeb 65 tu\u1ed5i tr\u1edf l\u00ean. Ngo\u00e0i ra, 90% ng\u01b0\u1eddi tham gia c\u00f3 b\u1ec7nh \u0111\u1ed3ng m\u1eafc \u1edf th\u1eddi \u0111i\u1ec3m \u0111\u00e1nh gi\u00e1 \u0111\u1ea7u v\u00e0o v\u00e0 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m kh\u00e1c khi\u1ebfn h\u1ecd c\u00f3 nguy c\u01a1 cao ti\u1ebfn tri\u1ec3n th\u00e0nh COVID-19 nghi\u00eam tr\u1ecdng, bao g\u1ed3m ung th\u01b0, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, b\u00e9o ph\u00ec, b\u1ec7nh ph\u1ed5i m\u00e3n t\u00ednh ho\u1eb7c hen suy\u1ec5n, b\u1ec7nh tim m\u1ea1ch ho\u1eb7c suy gi\u1ea3m mi\u1ec5n d\u1ecbch. Kho\u1ea3ng 62% l\u00e0 ng\u01b0\u1eddi da tr\u1eafng\/g\u1ed1c \u00c2u, 4% l\u00e0 ng\u01b0\u1eddi da m\u00e0u\/ng\u01b0\u1eddi M\u1ef9 g\u1ed1c Phi, 6% l\u00e0 ng\u01b0\u1eddi ch\u00e2u \u00c1 v\u00e0 24% l\u00e0 ng\u01b0\u1eddi M\u1ef9 b\u1ea3n \u0111\u1ecba ho\u1eb7c ng\u01b0\u1eddi b\u1ea3n \u0111\u1ecba Alaska. Kho\u1ea3ng 52% ng\u01b0\u1eddi tham gia l\u00e0 ng\u01b0\u1eddi g\u1ed1c T\u00e2y Ban Nha ho\u1eb7c M\u1ef9 La-tinh.<\/p>\n

AstraZeneca \u0111\u00e3 c\u00f4ng b\u1ed1 k\u1ebft qu\u1ea3 t\u1ed5ng qu\u00e1t t\u00edch c\u1ef1c t\u1eeb th\u1eed nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i tr\u00fa Evusheld <\/em>TACKLE pha III trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh.<\/p>\n

Evusheld<\/strong><\/p>\n

Evusheld<\/em>, tr\u01b0\u1edbc \u0111\u00e2y c\u00f3 t\u00ean l\u00e0 AZD7442, l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i \u2013 tixagevimab (AZD8895) v\u00e0 cilgavimab (AZD1061) \u2013 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o B do b\u1ec7nh nh\u00e2n ph\u1ee5c h\u1ed3i sau khi nhi\u1ec5m virus SARS-CoV-2 hi\u1ebfn t\u1eb7ng. \u0110\u01b0\u1ee3c kh\u00e1m ph\u00e1 b\u1edfi Trung t\u00e2m Y t\u1ebf \u0110\u1ea1i h\u1ecdc Vanderbilt v\u00e0 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p cho AstraZeneca v\u00e0o th\u00e1ng 6 n\u0103m 2020, c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u1ee7a ng\u01b0\u1eddi li\u00ean k\u1ebft v\u1edbi c\u00e1c v\u1ecb tr\u00ed ri\u00eang bi\u1ec7t tr\u00ean protein gai2<\/sup> c\u1ee7a SARS-CoV-2 v\u00e0 \u0111\u01b0\u1ee3c AstraZeneca t\u1ed1i \u01b0u h\u00f3a v\u1edbi th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i v\u00e0 gi\u1ea3m vi\u1ec7c li\u00ean k\u1ebft gi\u1eefa th\u1ee5 th\u1ec3 Fc v\u00e0 b\u1ed5 th\u1ec3 C1q3<\/sup>. Th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i gi\u00fap ho\u1ea1t \u0111\u1ed9ng c\u1ee7a kh\u00e1ng th\u1ec3 n\u00e0y c\u00f3 \u0111\u1ed9 b\u1ec1n h\u01a1n g\u1ea5p ba l\u1ea7n so v\u1edbi c\u00e1c kh\u00e1ng th\u1ec3 truy\u1ec1n th\u1ed1ng4-6<\/sup>; d\u1eef li\u1ec7u t\u1eeb th\u1eed nghi\u1ec7m PROVENT Giai \u0111o\u1ea1n III cho th\u1ea5y kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 k\u00e9o d\u00e0i \u00edt nh\u1ea5t s\u00e1u th\u00e1ng7<\/sup>. Vi\u1ec7c gi\u1ea3m li\u00ean k\u1ebft th\u1ee5 th\u1ec3 Fc nh\u1eb1m m\u1ee5c \u0111\u00edch gi\u1ea3m thi\u1ec3u nguy c\u01a1 t\u0103ng c\u01b0\u1eddng b\u1ec7nh t\u1eadt ph\u1ee5 thu\u1ed9c v\u00e0o kh\u00e1ng th\u1ec3 \u2013 m\u1ed9t hi\u1ec7n t\u01b0\u1ee3ng trong \u0111\u00f3 c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u v\u1edbi virus l\u1ea1i th\u00fac \u0111\u1ea9y, thay v\u00ec \u1ee9c ch\u1ebf, vi\u1ec7c l\u00e2y nhi\u1ec5m v\u00e0\/ho\u1eb7c ti\u1ebfn tri\u1ec3n b\u1ec7nh8<\/sup>.<\/p>\n

Ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u b\u1eb1ng ch\u1ee9ng t\u1eeb c\u00e1c th\u1eed nghi\u1ec7m trong ph\u00f2ng th\u00ed nghi\u1ec7m (in vitro) v\u00e0 tr\u00ean sinh v\u1eadt s\u1ed1ng (in vivo) cho th\u1ea5y kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 c\u1ee7a h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y tr\u01b0\u1edbc c\u00e1c bi\u1ebfn th\u1ec3 ph\u1ee5 c\u1ee7a Omicron v\u00e0 tr\u01b0\u1edbc t\u1ea5t c\u1ea3 c\u00e1c bi\u1ebfn th\u1ec3 \u0111\u00e1ng lo ng\u1ea1i kh\u00e1c \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m cho \u0111\u1ebfn hi\u1ec7n t\u1ea1i9-13<\/sup>. D\u1eef li\u1ec7u t\u1eeb \u0110\u1ea1i h\u1ecdc Y khoa Washington cho th\u1ea5y Evusheld<\/em> duy tr\u00ec kh\u1ea3 n\u0103ng trung h\u00f2a bi\u1ebfn th\u1ec3 ph\u1ee5 BA.2, c\u00f3 kh\u1ea3 n\u0103ng l\u00e2y lan nhanh v\u00e0 hi\u1ec7n \u0111ang l\u00e0 ch\u1ee7ng virus l\u01b0u h\u00e0nh m\u1ea1nh nh\u1ea5t tr\u00ean to\u00e0n c\u1ea7u9,14<\/sup>. Nghi\u00ean c\u1ee9u tr\u00ean c\u0169ng ch\u1ec9 ra r\u1eb1ng b\u1ed9 \u0111\u00f4i kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng n\u00e0y gi\u00fap gi\u1ea3m t\u1ea3i l\u01b0\u1ee3ng vi r\u00fat v\u00e0 thuy\u00ean gi\u1ea3m t\u00ecnh tr\u1ea1ng vi\u00eam nhi\u1ec5m \u1edf ph\u1ed5i (trong th\u1eed nghi\u1ec7m tr\u00ean sinh v\u1eadt s\u1ed1ng) \u0111\u1ed1i v\u1edbi bi\u1ebfn th\u1ec3 ph\u1ee5 BA.1, BA.1.1. v\u00e0 BA.2 c\u1ee7a Omicron9<\/sup>. Nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng m\u1edbi c\u1ee7a \u0110\u1ea1i h\u1ecdc Oxford \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y c\u0169ng duy tr\u00ec kh\u1ea3 n\u0103ng trung h\u00f2a ch\u1ed1ng l\u1ea1i c\u00e1c bi\u1ebfn th\u1ec3 m\u1edbi BA.4 v\u00e0 BA.5 c\u1ee7a Omicron.13<\/sup><\/p>\n

Evusheld <\/em>\u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh t\u1ea1i Li\u00ean minh ch\u00e2u \u00c2u v\u00e0 c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh c\u00f3 \u0111i\u1ec1u ki\u1ec7n b\u1edfi C\u1ee5c Qu\u1ea3n l\u00fd thu\u1ed1c v\u00e0 C\u00e1c s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe (MHRA) t\u1ea1i V\u01b0\u01a1ng qu\u1ed1c Anh cho d\u1ef1 ph\u00f2ng tr\u01b0\u1edbc ph\u01a1i nhi\u1ec5m COVID-19. Li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p cho d\u1ef1 ph\u00f2ng tr\u01b0\u1edbc ph\u01a1i nhi\u1ec5m COVID-19 t\u1ea1i Hoa K\u1ef3, \u0111\u1ed3ng th\u1eddi c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng v\u00e0 cung \u1ee9ng t\u1edbi nhi\u1ec1u qu\u1ed1c gia kh\u00e1c tr\u00ean th\u1ebf gi\u1edbi. H\u1ed3 s\u01a1 c\u1ea5p ph\u00e9p cho c\u1ea3 ch\u1ec9 \u0111\u1ecbnh d\u1ef1 ph\u00f2ng l\u1eabn \u0111i\u1ec1u tr\u1ecb COVID-19 \u0111ang \u0111\u01b0\u1ee3c x\u00fac ti\u1ebfn tr\u00ean to\u00e0n th\u1ebf gi\u1edbi.<\/p>\n

H\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 n\u00e0y \u0111ang \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a Ch\u00ednh ph\u1ee7 M\u1ef9, bao g\u1ed3m c\u00e1c qu\u1ef9 li\u00ean bang t\u1eeb B\u1ed9 Y t\u1ebf v\u00e0 D\u1ecbch v\u1ee5 Nh\u00e2n sinh; V\u0103n ph\u00f2ng Tr\u1ee3 l\u00fd B\u1ed9 tr\u01b0\u1edfng Chu\u1ea9n b\u1ecb v\u00e0 \u1ee8ng ph\u00f3; C\u01a1 quan Nghi\u00ean c\u1ee9u v\u00e0 Ph\u00e1t tri\u1ec3n Ti\u00ean ti\u1ebfn Y sinh h\u1ee3p t\u00e1c v\u1edbi B\u1ed9 Qu\u1ed1c ph\u00f2ng; V\u0103n ph\u00f2ng \u0110i\u1ec1u h\u00e0nh Ch\u01b0\u01a1ng tr\u00ecnh Chung v\u1ec1 Ph\u00f2ng th\u1ee7 H\u00f3a h\u1ecdc, Sinh h\u1ecdc, Ph\u00f3ng x\u1ea1 v\u00e0 H\u1ea1t nh\u00e2n, theo H\u1ee3p \u0111\u1ed3ng s\u1ed1 W911QY-21-9-0001.<\/p>\n

Theo c\u00e1c \u0111i\u1ec1u kho\u1ea3n c\u1ee7a th\u1ecfa thu\u1eadn c\u1ea5p ph\u00e9p v\u1edbi Vanderbilt, AstraZeneca s\u1ebd tr\u1ea3 ti\u1ec1n b\u1ea3n quy\u1ec1n m\u1ed9t ch\u1eef s\u1ed1 cho doanh thu thu\u1ea7n trong t\u01b0\u01a1ng lai.<\/p>\n

 <\/p>\n

AstraZeneca<\/strong><\/p>\n

AstraZeneca (LSE\/STO\/Nasdaq: AZN) l\u00e0 c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc to\u00e0n c\u1ea7u v\u1edbi chuy\u00ean m\u00f4n trong l\u0129nh v\u1ef1c ph\u00e1t minh, ph\u00e1t tri\u1ec3n v\u00e0 th\u01b0\u01a1ng m\u1ea1i h\u00f3a c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u1eb7c tr\u1ecb trong ba l\u0129nh v\u1ef1c ch\u00ednh: Ung th\u01b0, B\u1ec7nh hi\u1ebfm g\u1eb7p v\u00e0 D\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc, trong \u0111\u00f3 bao g\u1ed3m Tim m\u1ea1ch, Th\u1eadn & Chuy\u1ec3n h\u00f3a; v\u00e0 H\u00f4 h\u1ea5p & Mi\u1ec5n d\u1ecbch. \u0110\u1eb7t tr\u1ee5 s\u1edf t\u1ea1i Cambridge, V\u01b0\u01a1ng qu\u1ed1c Anh, AstraZeneca ho\u1ea1t \u0111\u1ed9ng t\u1ea1i h\u01a1n 100 qu\u1ed1c gia v\u00e0 c\u00e1c lo\u1ea1i thu\u1ed1c ti\u00ean ti\u1ebfn c\u1ee7a C\u00f4ng ty hi\u1ec7n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1edfi h\u00e0ng tri\u1ec7u b\u1ec7nh nh\u00e2n tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. \u0110\u1ec3 bi\u1ebft th\u00eam th\u00f4ng tin, vui l\u00f2ng truy c\u1eadp trang web www.astrazeneca.com v\u00e0 t\u00e0i kho\u1ea3n Twitter @AstraZeneca.<\/u><\/p>\n

Th\u00f4ng tin tham kh\u1ea3o<\/strong><\/p>\n

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  6. Domachowske JB et al. Safety, Tolerability and Pharmacokinetics of MEDI8897, an Extended Half-Life Single-Dose Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody Administered as a Single Dose to Healthy Preterm Infants. Pediatr Infect Dis J<\/em>. 2018;37(9):886-892<\/li>\n
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  14. World Health Organization. Weekly Epidemiological Update on COVID-19 – 25 May 2022. Available at: https:\/\/www.who.int\/publications\/m\/item\/weekly-epidemiological-update-on-covid-19—25-may-2022 [Last accessed: May 2022]<\/li>\n<\/ol>\n

     <\/p>\n

    \n

    Th\u00f4ng c\u00e1o b\u00e1o ch\u00ed ph\u00e1t h\u00e0nh b\u1edfi agency\u00a0Truy\u1ec1n th\u00f4ng EloQ<\/a>.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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